Abstract

Background: Genome-wide association studies have identified hundreds of susceptibility loci for various cancer sites including prostate cancer. Several of the risk loci have demonstrated pleiotropic effects with multiple cancers, suggesting shared biological pathways in carcinogenesis. In the present study, we systematically investigated the effects of other cancer-associated variants on prostate cancer risk.
Methods: We examined 196 genetic risk variants identified for 18 cancer and cancer-related traits in a total of 28,135 prostate cancer cases and 37,218 controls. This large meta-analysis of multiethnic samples was assembled from three consortia: Population Architecture using Genetics and Epidemiology (PAGE), Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) and Breast and Prostate Cancer Cohort Consortium (BPC3). Study- and ethnic-specific …

Metadata

publication

Cancer Research 74 (19_Supplement), 5064-5064, 2014

year

2014

publication date

2014/10/1

authors

Ying Han, Shelly-Ann Love, William S Bush, Daniele Campa, Anne M Butler, Logan Dumitrescu, Konstantinos Tsilidis, Iona Cheng, Lynne R Wilkens, Jay H Fowke, Jose Luis Ambite, Steve Buyske, S Lani Park, PRACTICAL Consortium, BPC3 Consortium, Christopher A Haiman, Loic L Marchand, Lucia A Hindorff, Federico Canzian, Fredrick R Schumacher

link

https://aacrjournals.org/cancerres/article/74/19_Supplement/5064/597245

journal

Cancer Research

volume

74

issue

19_Supplement

pages

5064-5064

publisher

The American Association for Cancer Research