Abstract

Common obesity risk variants have been associated with macronutrient intake; however, these associations' generalizability across populations has not been demonstrated. We investigated the associations between 6 obesity risk variants in (or near) the NEGR1, TMEM18, BDNF, FTO, MC4R, and KCTD15 genes and macronutrient intake (carbohydrate, protein, ethanol, and fat) in 3 Population Architecture using Genomics and Epidemiology (PAGE) studies: the Multiethnic Cohort Study (1993–2006) (n = 19,529), the Atherosclerosis Risk in Communities Study (1987–1989) (n = 11,114), and the Epidemiologic Architecture for Genes Linked to Environment (EAGLE) Study, which accesses data from the Third National Health and Nutrition Examination Survey (1991–1994) (n = 6,347). We used linear regression, with adjustment for age, sex, and ethnicity, to estimate the associations between obesity risk genotypes …

Metadata

publication

American journal of epidemiology 178 (5), 780-790, 2013

year

2013

publication date

2013/9/1

authors

Sungshim Lani Park, Iona Cheng, Sarah A Pendergrass, Anna M Kucharska-Newton, Unhee Lim, Jose Luis Ambite, Christian P Caberto, Kristine R Monroe, Fredrick Schumacher, Lucia A Hindorff, Matthew T Oetjens, Sarah Wilson, Robert J Goodloe, Shelly-Ann Love, Brian E Henderson, Laurence N Kolonel, Christopher A Haiman, Dana C Crawford, Kari E North, Gerardo Heiss, Marylyn D Ritchie, Lynne R Wilkens, Loïc Le Marchand

link

https://academic.oup.com/aje/article-abstract/178/5/780/87454

resource_link

https://academic.oup.com/aje/article/178/5/780/87454

journal

American journal of epidemiology

volume

178

issue

5

pages

780-790

publisher

Oxford University Press