Abstract

Acute kidney injury impacts ∼13.3 million individuals and causes ∼1.7 million deaths per year globally. Numerous injury pathways contribute to acute kidney injury, including cell cycle arrest, senescence, inflammation, mitochondrial dysfunction, and endothelial injury and dysfunction, and can lead to chronic inflammation and fibrosis. However, factors enabling productive repair versus nonproductive, persistent injury states remain less understood. The (Re)Building a Kidney (RBK) consortium is a National Institute of Diabetes and Digestive and Kidney Diseases consortium focused on both endogenous kidney repair mechanisms and the generation of new kidney tissue. This short review provides an update on RBK studies of endogenous nephron repair, addressing the following questions: (i) What is productive nephron repair? (ii) What are the cellular sources and drivers of repair? and (iii) How do RBK studies …

Metadata

publication

Kidney international 101 (5), 845-853, 2022

year

2022

publication date

2022/5/1

authors

Bilal A Naved, Joseph V Bonventre, Jeffrey A Hubbell, Neil A Hukriede, Benjamin D Humphreys, Carl Kesselman, M Todd Valerius, Andrew P McMahon, Stuart J Shankland, Jason A Wertheim, Michael JV White, Mark P de Caestecker, Iain A Drummond

link

https://www.sciencedirect.com/science/article/pii/S0085253822001831

resource_link

https://www.sciencedirect.com/science/article/pii/S0085253822001831

source

Kidney international

volume

101

issue

5

pages

845-853

publisher

Elsevier