Abstract

A 40-year-old male with Ph-positive CML underwent PBSC autografting after initial treatment with hydroxyurea and interferon. Following autograft he remained in chronic phase with cytogenetic or molecular evidence of low levels of residual Ph-positive cells. However, additional cytogenetic abnormalities, including t (3; 21) typically seen in therapy-related myelodysplastic syndrome (MDS) and AML and blast crisis of CML, developed as an independent cell line following the autograft. More than 4 years after the autograft, the patient remains in chronic phase with no evidence of accelerated phase or blast crisis of CML, but with a concurrent MDS. We report a case of CML who developed therapy-related MDS following PBSC autograft while still remaining in chronic phase.

Metadata

publication

Bone marrow transplantation 19 (12), 1255-1258, 1997

year

1997

publication date

1997/6

authors

A Jacob, M Griffiths, S Larkins, J Holmes

link

https://www.nature.com/articles/1700811

resource_link

https://www.researchgate.net/profile/Michael-Griffiths-11/publication/14011515_t321_following_peripheral_blood_stem_cell_transplantation_in_chronic_phase_chronic_myeloid_leukaemia/links/0f31753a59577d1d27000000/t321-following-peripheral-blood-stem-cell-transplantation-in-chronic-phase-chronic-myeloid-leukaemia.pdf

journal

Bone marrow transplantation

volume

19

issue

12

pages

1255-1258

publisher

Nature Publishing Group