Abstract

Structures of many large biomolecular assemblies are now being determined using integrative approaches. In these approaches, information derived from multiple experimental and computational methods is combined to compute three-dimensional structures of multi-protein complexes and other macromolecular machines. A standalone prototype data resource for integrative structures called PDB-Dev was built, based on recommendations of the Integrative and Hybrid Methods (IHM) Task Force of the Worldwide Protein Data Bank (wwPDB). This effort included developing data standards and software tools for collecting, curating, validating, visualizing, archiving, and disseminating integrative structures that span diverse spatiotemporal scales and conformational states. Mechanisms have been created to validate integrative structures based on the experimental data underpinning them. Building upon this …

Date

January 27, 2025

Authors

Brinda Vallat, Benjamin M Webb, Arthur Zalevsky, Hongsuda Tangmunarunkit, Monica R Sekharan, Serban Voinea, Aref Shafaeibejestan, Jared Sagendorf, Jeffrey C Hoch, Genji Kurisu, Kyle L Morris, Sameer Velankar, Carl Kesselman, Stephen K Burley, Helen M Berman, Andrej Sali

Journal

Journal of Molecular Biology

Pages

168963

Publisher

Academic Press